Luisa Spagnoli was a very modern woman, endowed with talent, great creativity and intuition. She founded two of the most important companies in Perugia, mainstays of the process of industrialization in the province: Perugina and Luisa Spagnoli. She was fifty years ahead of the evolution of the working woman, not just as a businesswoman but also for having brought women into industry.
In 1928 Luisa was the first to introduce the use of angora yarn for knitwear. She began raising a special breed of rabbit at her villa in Perugia, and at the same time built a workshop for the testing of spinning methods, yarns and knit fabrics, obtaining a thin, even yarn that she used to begin making elegant, high quality knitwear. She achieved great success in the fashion world of the time and developed a prosperous business, creating over one hundred jobs.